Computer systems are approaching human behavior in the sense of performing similar tasks, such as listening, understanding, thinking, and speaking. Although the forms of interaction with these systems have also followed the path of technology evolution, computer mice and keyboards do continue to play the leading role as a bridge between human and computer. The design of these devices forces the user to use their hands and this represents a major problem that has been already recognized in the literature with several pro- posed solutions. Nevertheless, in spite of the various methods found, it is difficult to find papers that make comparisons between them. Therefore, this work proposes an evaluation, using quantitative and qualitative analyses, of three alternative methods for mouse click: dwell time, mouth-puffing and electromyography. As result, both analyses showed that the interactions based on mouth-puffing and electromyography performed better than the dwell time method.